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Proposed mechanism of the abscopal effect. RT = radiation therapy; TNF-a = tumour necrosis factor α; IL-1a/b = interleukins 1α and 1β; IL-6 = interleukin 6; HMGB1 = high mobility group box 1 protein; ATP = adenosine triphosphate; MHC = major histocompatibility complex; ICAM = intercellular adhesion molecule; VCAM = vascular cell adhesion protein.
