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. 2018 Oct 28;24(40):4565–4577. doi: 10.3748/wjg.v24.i40.4565

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Kaplan-Meier survival plots for overall survival and relapse-free survival according to heparanase expression and Helicobacter pylori infection status. A: Heparanase (HPA) expression status (negative or positive) and the prognosis of all gastric cancer cases. HPA positive staining includes all cases of 1+, 2+, and 3+. HPA positive expression detected by immunohistochemical staining significantly predicts poor overall survival and relatively poor relapse-free survival; B: Kaplan-Meier survival according to HPA status in Helicobacter pylori positive gastric cancer cases. HPA positive expression significantly predicts poor overall survival as well as relapse-free survival. HPA: Heparanase; H. pylori: Helicobacter pylori.