Table 1.
Heparanase and mitogen-activated protein kinase expression in specimens of gastric cancer n (%)
| Cases (n) |
Immunohistochemical result |
HR (P value) | ||||
| - | + | ++ | +++ | |||
| HPA | ||||||
| Gastric cancer | 99 | 30 (30.3) | 16 (16.2) | 25 (25.3) | 28 (28.3) | 35.547 (0.000) |
| Para-cancer | 99 | 57 (57.6) | 11 (11.1) | 17 (17.2) | 16 (16.2)b | |
| Normal tissue | 25 | 24 (96.0) | 1 (4.0) | 0 (0.0) | 0 (0.0)bd | |
| MAPK | ||||||
| Gastric cancer | 99 | 49 (49.5) | 12 (12.1) | 19 (19.2) | 19 (19.2) | 33.303 (0.000) |
| Para-cancer | 99 | 82 (82.8) | 5 (5.1) | 6 (6.1) | 6 (6.1)b | |
| Normal tissue | 25 | 23 (92.0) | 2 (8.0) | 0 (0.0) | 0 (0.0)b | |
P values < 0.05 were determined using one way analysis of variance (ANOVA):
b
P: Comparison with gastric cancer;
d
P: Comparison with para-cancer tissue. HPA: Heparanase; MAPK: Mitogen-activated protein kinase; HR: Hazard ratio.