Table 3.
Correlation analyses of Helicobacter pylori infection, heparanase and mitogen-activated protein kinase expression, and gastric cancer pathological characteristics n (%)
| Parameter | Cases (n) |
H. pylori infection |
P value |
HPA expression |
P value |
MAPK expression |
P value | |||
| Positive | Negative | Positive | Negative | Positive | Negative | |||||
| Age (yr) | ||||||||||
| < 60 | 46 | 32 (32.3) | 14 (14.1) | 0.816 | 31 (31.3) | 14 (14.1) | 0.8731 | 22 (22.2) | 24 (24.2) | 0.619 |
| ≥ 60 | 53 | 38 (38.4) | 15 (15.2) | 38 (38.4) | 16 (16.2) | 28 (28.3) | 25 (25.3) | |||
| Gender | ||||||||||
| Male | 61 | 46 (46.5) | 15 (15.2) | 0.193 | 42 (42.4) | 18 (18.2) | 0.935 | 27 (27.3) | 34 (34.3) | 0.115 |
| Female | 38 | 24 (24.2) | 14 (14.1) | 27 (27.3) | 12 (12.1) | 23 (23.2) | 15 (15.2) | |||
| Lymph node metastasis | ||||||||||
| Without | 42 | 24 (24.2) | 18 (18.2) | 0.011 | 23 (23.2) | 19 (19.2) | 0.006 | 24 (24.2) | 18 (18.2) | 0.257 |
| With | 57 | 46 (46.5) | 11 (11.1) | 46 (46.5) | 11 (11.1) | 26 (26.3) | 31 (31.3) | |||
| Tumour diameter | ||||||||||
| < 40 mm | 57 | 40 (40.4) | 17 (17.2) | 0.892 | 39 (39.4) | 17 (17.2) | 0.989 | 25 (25.3) | 32 (32.3) | 0.123 |
| ≥ 40 mm | 42 | 30 (30.3) | 12 (12.1) | 30 (30.3) | 13 (13.1) | 25 (25.3) | 17 (17.2) | |||
| Differentiation degree | ||||||||||
| Poorly | 40 | 28 (28.3) | 12 (12.1) | 0.899 | 26 (26.3) | 14 (14.1) | 0.402 | 23 (23.2) | 17 (17.2) | 0.252 |
| Highly and moderately | 59 | 42 (42.4) | 17 (17.2) | 43 (43.3) | 16 (16.2) | 27 (27.3) | 32 (32.3) | |||
| Invasive depth | ||||||||||
| T1/2 | 39 | 31 (31.3) | 8 (8.1) | 0.122 | 33 (33.3) | 6 (6.1) | 0.009 | 24 (24.2) | 15 (15.2) | 0.077 |
| T3/4 | 60 | 39 (39.4) | 21 (21.2) | 36 (36.4) | 24 (24.2) | 26 (26.3) | 34 (34.3) | |||
HPA: Heparanase; MAPK: Mitogen-activated protein kinase; H. pylori: Helicobacter pylori.