Table 3. Meta-analysis of the association between CALM1 polymorphisms and OA risk.
| SNP | Comparison | Category | Category | Studies | OR (95% CI) | P-value | P for heterogeneity |
|---|---|---|---|---|---|---|---|
| rs12885713 | T vs. C | Total (Fixed model) | 5 | 1.11 (1.02–1.22) | 0.022 | 0.221 | |
| Allele model | Ethnicity | Asian | 2 | 1.24 (1.03–1.51) | 0.024 | 0.140 | |
| Caucasian | 3 | 1.08 (0.97–1.19) | 0.165 | 0.410 | |||
| OA type | Knee | 3 | 1.13 (0.99–1.30) | 0.079 | 0.735 | ||
| Hip | 2 | 1.10 (0.97–1.23) | 0.131 | 0.026 | |||
| Genotype method | TaqMan | 2 | 1.24 (1.08–1.43) | 0.002 | 0.286 | ||
| PCR-RFLP | 3 | 1.03 (0.91–1.16) | 0.665 | 0.792 | |||
| TT + TC vs. CC | Total (Fixed model) | 5 | 1.14 (0.99–1.32) | 0.071 | 0.732 | ||
| Dominant model | Ethnicity | Asian | 2 | 1.13 (0.89–1.43) | 0.324 | 0.327 | |
| Caucasian | 3 | 1.15 (0.96–1.38) | 0.129 | 0.594 | |||
| OA type | Knee | 3 | 1.15 (0.93–1.43) | 0.201 | 0.470 | ||
| Hip | 2 | 1.14 (0.93–1.38) | 0.202 | 0.480 | |||
| Genotype method | TaqMan | 2 | 1.26 (1.03–1.56) | 0.028 | 0.793 | ||
| PCR-RFLP | 3 | 1.04 (0.85–1.27) | 0.699 | 0.895 | |||
| TT vs. TC + CC | Total (Random model) | 5 | 1.30 (0.96–1.76) | 0.086 | 0.023 | ||
| Recessive model | Ethnicity | Asian | 5 | 2.21 (1.39–3.50) | 0.001 | 0.234 | |
| Caucasian | 2 | 1.07 (0.91–1.25) | 0.410 | 0.430 | |||
| OA type | Knee | 3 | 1.20 (0.95–1.52) | 0.120 | 0.902 | ||
| Hip | 2 | 1.54 (0.60–3.93) | 0.371 | 0.001 | |||
| Genotype method | TaqMan | 2 | 1.67 (0.77–3.61) | 0.192 | 0.010 | ||
| PCR-RFLP | 3 | 1.03 (0.86–1.24) | 0.742 | 0.514 | |||
| TT vs. CC | Total (Random model) | 5 | 1.40 (1.02–1.91) | 0.037 | 0.078 | ||
| Homozygote model | Ethnicity | Asian | 2 | 2.05 (1.06–3.97) | 0.033 | 0.212 | |
| Caucasian | 3 | 1.18 (0.96–1.46) | 0.120 | 0.480 | |||
| OA type | Knee | 3 | 1.34 (1.01–1.80) | 0.045 | 0.987 | ||
| Hip | 2 | 1.60 (0.65–3.90) | 0.305 | 0.004 | |||
| Genotype method | TaqMan | 2 | 1.82 (0.97–3.40) | 0.063 | 0.051 | ||
| PCR-RFLP | 3 | 1.10 (0.85–1.42) | 0.475 | 0.774 | |||
| TC vs. CC | Total (Fixed model) | 5 | 1.08 (0.93–1.26) | 0.332 | 0.800 | ||
| Heterozygote model | Ethnicity | Asian | 2 | 0.99 (0.77–1.28) | 0.951 | 0.663 | |
| Caucasian | 3 | 1.13 (0.93–1.37) | 0.206 | 0.672 | |||
| OA type | Knee | 3 | 1.10 (0.88–1.38) | 0.411 | 0.462 | ||
| Hip | 2 | 1.06 (0.86–1.30) | 0.572 | 0.827 | |||
| Genotype method | TaqMan | 2 | 1.14 (0.91–1.43) | 0.246 | 0.380 | ||
| PCR-RFLP | 3 | 1.03 (0.83–1.27) | 0.813 | 0.811 | |||
| rs2300496 | C vs. A | Total (Fixed model) | 2 | 1.23 (1.07–1.42) | 0.003 | 0.329 | |
| Allele model | |||||||
| CC + CA vs. AA dominant model | Total (Fixed model) | 2 | 1.21 (0.99–1.48) | 0.059 | 0.955 | ||
| CC vs. CA + AA | Total (Random model) | 2 | 1.67 (0.85–3.27) | 0.133 | 0.024 | ||
| Recessive model | |||||||
| CC vs. AA | Total (Random model) | 2 | 1.75 (0.95–3.21) | 0.072 | 0.055 | ||
| Homozygote model | |||||||
| CA vs. CC | Total (Fixed model) | 2 | 1.09 (0.88–1.35) | 0.432 | 0.641 | ||
| Heterozygote model | |||||||
| rs3213718 | T vs. C | Total (Fixed model) | 1.09 (0.98-1.21) | 0.105 | 0.153 | ||
| Allele model |
*Bold values are statistically significant (P<0.05).