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. 2018 Sep 17;3(5):337–344. doi: 10.1002/lio2.180

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© 2018 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Organization and cellular renewal in the OE. (A) In normal un–damaged OE, cells are pseudostratified with sustentacular (SUS) and microvillar (Mv) cells in the apical layer, fully differentiated mature olfactory sensory neurons (mOSN) in the upper/middle layers, immature neurons (iOSN) deep to the mOSNs, and two progenitor populations in the basal germinal zone: proliferative globose basal cells (GBCs) and reserve horizontal basal cells (HBCs). Also indicated are the acinar and duct structures of Bowman's glands (BG). (B) Following injury, the OE is normally reconstituted from spared basal stem cells, the HBCs and GBCs. Arrows indicate the lineage relationships as OE cells are produced from stem and progenitor cells.