Figure 3.
Schematic of the distribution of positive variants in our meta-analysis across the whole SNCA gene. (A) ATG indicates the start codon and TAA indicates the end codon. SNCA contains six exons and all of the positive SNPs (red markers represent the SNPs with p < 1 × 10−5 and orange markers represent the SNPs with p < 0.05) in our analysis were in non-coding regions of SNCA. (B) In terms of the haplotype analysis with public data from 1000 Genomes Project, the 8 red significant SNPs could be divided into two blocks: the first block contained variants rs2737029 and rs356186, the second block contained variants rs2736990, rs356165, rs356220, rs356219, and rs181489. The variants in the same block indicated that any of the two variants exposed LD.