Table 2.
Meta-analysis of the risk alleles of SNCA in each group.
| Variants | Alleles and related data | In total | East Asian | European | Mixed* | Latino | West Asian* | |
|---|---|---|---|---|---|---|---|---|
| rs181489 | T | OR (95%CI) | 1.28 [1.17, 1.40] | – | 1.27 [1.15, 1.39] | – | – | – |
| p-value | <0.00001 | – | <0.00001 | – | – | – | ||
| AF (P) | 0.3486 | – | 0.3479 | 0.359 | – | – | ||
| AF (C) | 0.2974 | – | 0.299 | 0.2792 | – | – | ||
| AF (G) | 0.2531 | 0.0006 | 0.3071 | – | 0.1866 | – | ||
| rs356165 | G | OR (95%CI) | 1.25 [1.15, 1.37] | 1.14 [0.97, 1.34] | 1.37 [1.25, 1.50] | – | – | – |
| p-value | <0.00001 | 0.11 | <0.00001 | – | – | – | ||
| AF (P) | 0.5117 | 0.5982 | 0.4098 | 0.4512 | – | – | ||
| AF (C) | 0.4631 | 0.5489 | 0.3399 | 0.3979 | – | – | ||
| AF (G) | 0.4601 | 0.5293 | 0.3654 | – | 0.4688 | – | ||
| rs356186 | A | OR (95%CI) | 0.77 [0.70, 0.86] | – | 0.77 [0.70, 0.86] | – | – | – |
| p-value | <0.00001 | – | <0.00001 | – | – | – | ||
| AF (P) | 0.1629 | – | 0.1629 | – | – | – | ||
| AF (C) | 0.2008 | – | 0.2008 | – | – | – | ||
| AF (G) | 0.194 | 0.1559 | 0.2 | – | 0.244 | – | ||
| rs356219 | G | OR (95%CI) | 1.30 [1.23, 1.38] | 1.39 [1.15, 1.68] | 1.26 [1.19, 1.34] | – | – | – |
| p-value | <0.00001 | 0.0007 | <0.00001 | – | – | – | ||
| AF (P) | 0.4723 | 0.6356 | 0.4367 | 0.452 | 0.6058 | – | ||
| AF (C) | 0.4038 | 0.555 | 0.3776 | 0.3483 | 0.4745 | – | ||
| AF (G) | 0.4549 | 0.5276 | 0.3654 | – | 0.4677 | – | ||
| rs356220 | T | OR (95%CI) | 1.23 [1.14, 1.33] | – | – | – | ||
| p-value | <0.00001 | – | – | – | ||||
| AF (P) | 0.4865 | 0.5907 | 0.4181 | – | – | 0.4154 | ||
| AF (C) | 0.4363 | 0.5543 | 0.3715 | – | – | 0.3442 | ||
| AF (G) | 0.4543 | 0.5224 | 0.3608 | – | 0.4513 | – | ||
| rs356221 | A | OR (95%CI) | 1.15 [0.94, 1.40] | 1.15 [0.85, 1.55] | – | – | – | – |
| p-value | 0.16 | 0.37 | – | – | – | – | ||
| AF (P) | 0.6257 | 0.664 | 0.4879 | – | – | – | ||
| AF (C) | 0.5963 | 0.628 | 0.459 | – | – | – | ||
| AF (G) | 0.5591 | 0.605 | 0.4584 | – | 0.5252 | – | ||
| rs894278 | G | OR (95%CI) | 1.13 [0.87, 1.46] | 1.13 [0.87, 1.46] | – | – | – | – |
| p-value | 0.37 | 0.37 | – | – | – | – | ||
| AF (P) | 0.3926 | 0.3926 | – | – | – | – | ||
| AF (C) | 0.3626 | 0.3626 | – | – | – | – | ||
| AF (G) | 0.1479 | 0.368 | 0.0482 | – | 0.1878 | – | ||
| rs2301134 | A | OR (95%CI) | 1.00 [0.74, 1.34] | – | – | – | – | – |
| p-value | 0.97 | – | – | – | – | – | ||
| AF (P) | 0.2559 | 0.1245 | 0.5312 | – | – | – | ||
| AF (C) | 0.2454 | 0.1301 | 0.5066 | – | – | – | ||
| AF (G) | 0.4248 | 0.1582 | 0.4935 | – | 0.4079 | – | ||
| rs2301135 | G | OR (95%CI) | 1.24 [0.87, 1.76] | – | 1.07 [0.98, 1.17] | – | – | – |
| p-value | 0.23 | – | 0.13 | – | – | – | ||
| AF (P) | 0.3559 | 0.0873 | 0.5188 | – | – | – | ||
| AF (C) | 0.3581 | 0.0799 | 0.502 | – | – | – | ||
| AF (G) | 0.4179 | 0.1591 | 0.4944 | – | 0.406 | – | ||
| rs2583988 | T | OR (95%CI) | 1.21 [1.08, 1.35] | – | 1.16 [1.04, 1.31] | – | – | – |
| p-value | 0.001 | – | 0.009 | – | – | – | ||
| AF (P) | 0.2981 | – | 0.2968 | – | 0.2885 | – | ||
| AF (C) | 0.2648 | – | 0.2682 | – | 0.1939 | – | ||
| AF (G) | 0.1982 | 0.1495 | 0.2676 | – | 0.1495 | – | ||
| rs2619363 | T | OR (95%CI) | 1.13 [1.02, 1.24] | – | 1.13 [1.02, 1.24] | – | – | – |
| p-value | 0.01 | – | 0.01 | – | – | – | ||
| AF (P) | 0.3051 | – | 0.3051 | – | – | – | ||
| AF (C) | 0.2802 | – | 0.2802 | – | – | – | ||
| AF (G) | 0.1887 | 0.0006 | 0.2674 | – | 0.1504 | – | ||
| rs2619364 | G | OR (95%CI) | 1.24 [1.11, 1.40] | – | 1.24 [1.11, 1.40] | – | – | – |
| p-value | 0.0003 | – | 0.0003 | – | – | – | ||
| AF (P) | 0.302 | – | 0.302 | – | – | – | ||
| AF (C) | 0.2587 | – | 0.2587 | – | – | – | ||
| AF (G) | 0.1891 | 0.0006 | 0.2676 | – | 0.1495 | – | ||
| rs2736990 | G | OR (95%CI) | 1.22 [1.13, 1.31] | 1.22 [1.11, 1.35] | – | – | – | – |
| p-value | <0.00001 | <0.0001 | – | – | – | – | ||
| AF (P) | 0.6092 | 0.6618 | 0.5101 | – | 0.6587 | – | ||
| AF (C) | 0.5602 | 0.6191 | 0.47 | – | 0.5255 | – | ||
| AF (G) | 0.554 | 0.6117 | 0.457 | – | 0.524 | – | ||
| rs2737029 | G | OR (95%CI) | 1.38 [1.20, 1.59] | – | 1.30 [1.16, 1.45] | – | – | – |
| p-value | <0.00001 | – | <0.00001 | – | – | – | ||
| AF (P) | 0.5205 | 0.6842 | 0.4451 | – | – | – | ||
| AF (C) | 0.4478 | 0.5756 | 0.3839 | – | – | – | ||
| AF (G) | 0.4505 | 0.5437 | 0.3903 | – | – | – | ||
| rs7684318 | C | OR (95%CI) | 1.53 [1.22, 1.91] | 1.53 [1.22, 1.91] | – | – | – | – |
| p-value | 0.0003 | 0.0003 | – | – | – | – | ||
| AF (P) | 0.5913 | 0.5913 | – | – | – | – | ||
| AF (C) | 0.5229 | 0.5229 | – | – | – | – | ||
| AF (G) | 0.1912 | 0.5318 | 0.057 | – | 0.2818 | – | ||
| rs11931074 | T | OR (95%CI) | 1.36 [1.29, 1.44] | 1.34 [1.26, 1.44] | 1.37 [1.24, 1.52] | – | – | – |
| p-value | <0.00001 | <0.00001 | <0.00001 | – | – | – | ||
| AF (P) | 0.2825 | 0.6023 | 0.0917 | 0.1008 | 0.2932 | 0.325 | ||
| AF (C) | 0.2501 | 0.5297 | 0.069 | 0.076 | 0.2296 | 0.2404 | ||
| AF (G) | 0.2344 | 0.5281 | 0.0623 | – | 0.2936 | – | ||
The bold characters and numbers represent the most recommended variants and corresponding relevant data (p < 1 × 10−5).
AF, allele frequency; P, patients; C, controls; G, GnomAD database; OR, odds ratio; CI, confidence interval;
*
no related AF in the GnomAD database.