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. 2018 Oct 25;9:630. doi: 10.3389/fendo.2018.00630

Figure 1.

Figure 1

Sodium butyrate treatment decreases blood glucose level and delays the onset of diabetes. Male BALB/c mice received STZ treatment by i.p. route at a dose of 40 mg/kg/day for 5 consecutive days. Sodium butyrate (dose of 500 mg/kg/day, n = 9) or vehicle treatment (n = 8) from day 6 (solid line labeled) for 7 consecutive days after the last STZ injection. (A) STZ induced diabetic mice exhibited lower blood glucose when receiving sodium butyrate treatment compared with vehicle from day 11 (*p < 0.05). (B) Treatment with sodium butyrate decreased diabetes incidence and delayed the onset of diabetes (*p < 0.01). (C) Sodium butyrate treatment had no effect on the body weight of the diabetic mice.