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. 2018 Oct 25;6:156. doi: 10.3389/fbioe.2018.00156

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Copyright © 2018 Pill, Melke, Mühleder, Pultar, Rohringer, Priglinger, Redl, Hofmann and Holnthoner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASC induce a denser network of tubular structures in EC than BMSC in a 3D fibrin matrix, while in both groups the networks remain stable over 3 weeks of culture. (A) Representative fluorescent images from all three groups (ASC + EC, BMSC + EC, and EC only) at all-time points. EC are depicted in green. (B) Network parameters number of junctions, number of tubules and total tubule length were significantly higher and mean tubule length significantly lower in ASC + EC compared to BMSC + EC co-cultures at all time-points. All parameters changed significantly in ASC + EC between day 7 and day14/day21. n = 16 from four biological replicates (each in technical duplicate), comparing two different donors of each cell type, **p < 0.01, ***p < 0.001. Scale bar: 300 μm.