Table V.

Adjusted Cox regression analysis for risk of death and logistic regression analysis for the composite endpoint with baseline TSH (n = 614) in two models, stratified by gender

Variable	Men (N = 302)				Women (N = 312)
	Death		Composite endpoint		Death		Composite endpoint
	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI
	N = 36		N = 106		N = 28		N = 99
Model 1:
Age, 11 years	2.31	1.51–3.55	1.51	1.14–1.98	1.76	1.08–2.85	1.46	1.10–1.90
TSH mid-tertile 1.36/1.76 mIU/l	0.84	0.34–2.12	1.02	0.56–1.83	3.87	0.84–13.2	1.37	0.74–2.53
TSH high tertile 2.56/3.36 mIU/l	0.91	0.37–2.20	1.01	0.55–1.84	9.70	2.27–29.8	2.13	1.14–3.98
Free T3, 0.34/0.32 pg/ml	0.71	0.24–2.15	1.51	0.73–3.11	0.32	0.08–1.37	1.47	0.68–3.18
Free T4, 015/0.15 ng/dl	4.68	0.50–43.5	1.34	0.27–6.66	98.9	7.83–1250	5.14	1.02–25.9
Model 2:	29/286↑		97/286↑		24/304↑		92/304↑
Age, 11 years	2.04	1.34–3.09	1.46	1.10–1.96	2.10	1.02–4.39	1.51	1.00–2.26
TSH mid-tertile 1.36/1.76 mIU/l	0.92	0.35–2.42	1.10	0.59–2.05	2.75	0.60–12.7	1.09	0.57–2.09
TSH high tertile 2.56/3.36 mIU/l	1.05	0.42–2.64	1.20	0.64–2.25	9.89	2.50–39.1	2.02	1.07–3.82
Free T3, 0.34/0.32 pg/ml	0.70	0.22–2.25	1.66	0.77–3.58	0.35	0.07–1.71	1.57	0.70–3.54
Free T4, 0.15/0.15 ng/dl	9.73	1.04–90.7	1.44	0.28–7.49	66.6	4.33–1022	4.63	0.84–25.4
Systolic BP, 14 mm Hg	0.71	0.46–1.10	1.09	0.81–1.45	0.78	0.49–1.21	1.27	0.99–1.60
Total cholesterol, 40 mg/dl	0.89	0.64–1.22	1.00	0.82–1.22	0.99	0.59–1.38	1.08	0.85–1.38
Menopause, yes/no					0.50	0.09–3.15	0.81	0.32–2.06

Referents were lowest TSH tertile 0.70/0.83 mIU/l in men and women, respectively. Values were missing in < 4% of the sample in model 2. Numbers in boldface denote significantly and those in italics borderline significantly associated values. Numbers next to the continuous independent variables denote 1 SD increment, those next to the categorical variables denote mean values, in men and women, respectively”.

^↑number of cases/number at risk. Menopause was present in 226 women.