Table IV.
Metabolic traits of the samples stratified by genotype
| dbSNP Genotype | BMI [kg/m2] | SBP [mm Hg] | DBP [mm Hg] | CHOL [mg/dl] | Glucose [mg/dl] | TRG [mg/dl] | HDL [mg/dl] | Insulin [mU/ml] | HbA1c (%) | HOMA-IR | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs10811661 | T/T | 28 (26–32) | 131 (120–148) | 76 (68.5–83) | 195 (169.5–218) | 119 (94–164.5) | 171 (127.5–245.5) | 39 (34–46) | 9 (6–13) | 8 (7–10) | 2.82 (1.81–4.43) |
| C/T | 28.5 (25–31.75) | 135 (121–151) | 77 (69–82) | 186 (165–214) | 122 (97–155) | 168 (111–214) | 38 (33–44) | 5 (4–9) | 8 (7–10) | 1.74 (0.96–3.88) | |
| C/C | 31 (26–33) | 137 (120–138) | 76 (69–77) | 211 (197–217) | 150 (141–312) | 168 (149–272) | 47 (42–51) | 4 (3–6) | 14 (7–15) | 2.22 (1.18–2.38) | |
| P | 0.966 | 0.096 | 0.988 | 0.089 | 0.093 | 0.08 | 0.086 | 0.111 | 0.133 | 0.089 | |
| rs8192678 | C/C | 28 (26–31) | 132 (120–148) | 76 (68–82) | 187 (168–216) | 121 (95.5–172.5) | 169 (125.5–245) | 38 (33–45) | 7 (4–11) | 8 (7–10) | 2.28 (140–3.85) |
| C/T | 29 (25.5–32) | 134 (123–148) | 76 (69–83) | 199 (171.5–220.5) | 114 (94–150.5) | 173 (131–254) | 42 (35–49) | 10 (7–14) | 8 (7–10) | 3.00 (1.86–4.68) | |
| T/T | 27 (25.5–30.5) | 136 (121.5–158.5) | 79 (70.5–85) | 199 (179.5–224.5) | 130 (97–192.5) | 156 (128–178) | 42 (33–45) | 12.5 (8–24.5) | 8 (7–10) | 4.60 (2.88–6.45) | |
| P | 0.651 | 0.078 | 0.073 | 0.063 | 0.023 | 0.013 | 0.087 | 0.092 | 0.314 | 0.065 | |
| rs2010963 | C/C | 29 (26–32) | 137 (123.5–148.75) | 77 (70–82.75) | 183 (164.75–214.75) | 128 (97–174.5) | 149.5 (109.75–248) | 38 (33.75–47.25) | 4 (3–9) | 8 (7–10) | 1.74 (0.97–3.79) |
| C/G | 29 (26–33) | 130 (118–147) | 74 (67–81) | 188 (169–214) | 119 (96–168) | 169 (127–231) | 38 (33–44) | 7 (5–11) | 8.5 (7–10.75) | 2.33 (1.47–3.64) | |
| G/G | 28 (25–31) | 134.5 (122–148) | 76 (69–83) | 199 (170.75–224.25) | 115.5 (93.75–157) | 174 (132.75–252.25) | 41 (34.75–49) | 10 (7–14) | 8 (7–10) | 3.05 (1.90–4.90) | |
| P | 0.175 | 0.06 | 0.012 | 0.013 | 0.14 | 0.081 | 0.0007* | 0.105 | 0.416 | 0.09 | |
| rs7896005 | A/A | 28 (25–31) | 132 (120–148) | 76 (67–80.25) | 187.5 (168–215.25) | 122 (95–172.25) | 168 (122.75–245.25) | 38 (33–45) | 6 (4–11) | 8 (7–11) | 2.19 (1.30–3.56) |
| A/G | 28 (26–32) | 135 (122.25–147.75) | 76 (69–83) | 195.5 (168–217.75) | 119.5 (96.5–157.75) | 174 (131.25–245.5) | 39 (34–48.75) | 9 (6–13) | 8 (7–10) | 2.65 (1.79–4.58) | |
| G/G | 28 (25–32) | 134 (118.5–154) | 79 (69.5–86) | 203 (182–231) | 110 (92.5–166.5) | 161 (127–248.5) | 42 (35–45) | 12 (10–19.5) | 8 (6.5–10) | 3.72 (2.88–6.33) | |
| P | 0.867 | 0.075 | 0.012 | 0.065 | 0.07 | 0.051 | 0.106 | 0.011 | 0.592 | 0.107 | |
| rs659366 | C/C | 29 (26–32) | 134.5 (120–148) | 76 (68.75–80) | 181 (164–216) | 117.5 (94.5–156.5) | 169.5 (109.75–242) | 32 (28–45) | 5 (4–10) | 8 (7–10) | 1.89 (1.14–3.54) |
| C/T | 28 (25–31) | 130 (120–147.25) | 76 (69–84) | 199 (170.5–217) | 121 (95.75–175.25) | 173 (130–248) | 39 (34–46) | 8 (5–12) | 8 (7–10) | 2.68 (1.82–4.17) | |
| T/T | 28 (26–32) | 136 (123–151) | 76 (69–82.5) | 199 (177–229) | 118 (94–155.5) | 165 (128.5–238) | 42 (35–49) | 11 (7–16) | 8 (7–10) | 3.11 (2.04–6.16) | |
| P | 0.401 | 0.06 | 0.634 | 0.034 | 0.031 | 0.028 | 0.06 | 0.17 | 0.286 | 0.104 | |
dbSNP – the single nucleotide polymorphism database, medians (25–75 percentile), BMI – body max index, SBP – systolic blood pressure, DBP – diastolic blood pressure, CHOL – cholesterol, TRG – triglycerides, HDL – high-density lipoprotein, HbA1c – glycated haemoglobin, HOMA-IR – homeostasis model assessment of insulin resistance. Nominal significance between 0.01 > and < 0.05
*
Significant p-value < 0.01, after Bonferroni correction.