Table 4.
Haemodynamic responses to NE‐induced vasoconstriction
| Before NE | After NE | |||||||
|---|---|---|---|---|---|---|---|---|
| Drug condition | Muscle contractile status | Group | MAP (mmHg) | MABF (mL/min) | MVC (mL/min/mmHg/100 mL) | MAP (mmHg) | MABF (mL/min) | MVC (mL/min/mmHg/100 mL) |
| Baseline | ||||||||
| Rest | ||||||||
| Normal | 66.76 ± 3.86 | 99.87 ± 19.00 | 0.46 ± 0.05 | 69.19 ± 3.28 | 41.67 ± 13.00* | 0.19 ± 0.05* | ||
| DMD | 72.14 ± 4.21 | 52.60 ± 7.14† | 0.38 ± 0.04 | 71.40 ± 3.75 | 11.96 ± 2.12* , † | 0.08 ± 0.01* , † | ||
| Contraction | ||||||||
| Normal | 67.17 ± 4.86 | 123.18 ± 26.55 | 0.54 ± 0.07 | 67.84 ± 4.60 | 88.33 ± 21.72* | 0.37 ± 0.06* | ||
| DMD | 71.66 ± 4.04 | 63.99 ± 7.05† | 0.48 ± 0.05 | 71.89 ± 3.90 | 27.44 ± 3.51* , † | 0.21 ± 0.03* , † | ||
| After 7‐NI | ||||||||
| Rest | ||||||||
| Normal | 66.19 ± 4.66 | 95.76 ± 16.44 | 0.46 ± 0.05 | 66.58 ± 4.05 | 44.32 ± 10.79* | 0.22 ± 0.05* | ||
| DMD | 64.96 ± 3.33 | 48.66 ± 5.13† | 0.40 ± 0.04 | 64.99 ± 3.30 | 8.84 ± 1.41* , † | 0.08 ± 0.01* , † | ||
| Contraction | ||||||||
| Normal | 64.46 ± 3.28 | 119.83 ± 20.49 | 0.58 ± 0.06 | 65.52 ± 3.85 | 71.12 ± 13.65* | 0.34 ± 0.05* | ||
| DMD | 64.93 ± 3.48 | 59.29 ± 5.77† | 0.50 ± 0.05 | 64.42 ± 3.27 | 22.59 ± 2.76* , † | 0.20 ± 0.04* , † | ||
| After l‐NAME | ||||||||
| Rest | ||||||||
| Normal | 83.74 ± 3.31 | 126.98 ± 16.82 | 0.50 ± 0.06 | 84.26 ± 3.86 | 58.66 ± 12.10* | 0.23 ± 0.05* | ||
| DMD | 80.26 ± 4.17 | 59.99 ± 5.89† | 0.40 ± 0.04 | 81.41 ± 3.69 | 13.43 ± 1.75* , † | 0.10 ± 0.02* , † | ||
| Contraction | ||||||||
| Normal | 81.57 ± 3.72 | 158.43 ± 24.15 | 0.61 ± 0.08 | 82.43 ± 3.50 | 91.27 ± 15.04* | 0.35 ± 0.06* | ||
| DMD | 83.05 ± 3.75 | 73.13 ± 6.10† | 0.48 ± 0.05 | 83.40 ± 3.60 | 29.47 ± 2.90* , † | 0.21 ± 0.04* , † | ||
Abbreviations: NE, noradrenaline; MAP, mean arterial pressure; MABF, mean arterial blood flow; MVC, mean vascular conductance; DMD, Duchenne muscular dystrophy. *Significantly different from before NE. †Significantly different from normal.