Table 5.
Change in haemodynamic responses to NE‐induced vasoconstriction
| Drug condition | Muscle contractile status | Group | ∆MAP (mmHg) | ∆MABF (mL/min) | ∆MVC (mL/min/mmHg/100 mL) |
|---|---|---|---|---|---|
| Baseline | |||||
| Rest | |||||
| Normal | 2.43 ± 1.10 | −58.20 ± 10.76 | −0.27 ± 0.03 | ||
| DMD | −0.74 ± 0.87 | −40.64 ± 5.64 | −0.29 ± 0.03 | ||
| Contraction | |||||
| Normal | 0.67 ± 0.75 | −34.85 ± 8.97* | −0.16 ± 0.03* | ||
| DMD | 0.23 ± 0.77 | −36.56 ± 4.85 | −0.27 ± 0.03 | ||
| After 7‐NI | |||||
| Rest | |||||
| Normal | 0.39 ± 4.05 | −51.43 ± 9.76 | −0.24 ± 0.02 | ||
| DMD | 0.02 ± 1.22 | −39.83 ± 4.27 | −0.32 ± 0.03 | ||
| Contraction | |||||
| Normal | 1.07 ± 1.54 | −48.71 ± 8.48 | −0.24 ± 0.03 | ||
| DMD | −0.51 ± 1.47 | −36.70 ± 4.49 | −0.29 ± 0.03 | ||
| After l‐NAME | |||||
| Rest | |||||
| Normal | 0.52 ± 1.13 | −68.32 ± 9.73 | −0.27 ± 0.03 | ||
| DMD | 1.15 ± 1.20 | −46.56 ± 5.29 | −0.30 ± 0.03 | ||
| Contraction | |||||
| Normal | 0.87 ± 0.95 | −67.17 ± 12.47† | −0.26 ± 0.03 | ||
| DMD | 0.35 ± 1.16 | −43.66 ± 5.47 | −0.27 ± 0.03 | ||
Abbreviations: MAP, mean arterial pressure; MABF, mean arterial blood flow; MVC, mean vascular conductance; DMD, Duchenne muscular dystrophy. *Significantly different from normal at rest. †Significantly different from normal at baseline and after 7‐NI.