Table 5. Association of perioperative factors with the risk of CSM among patients with high-risk PCa who achieved undetectable PSA levels following radical prostatectomy.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age, yr | 0.956 | 0.881–1.037 | 0.277 | - | - | - |
| BMI | 1.055 | 0.783–1.421 | 0.724 | - | - | - |
| PSA | 1.006 | 0.994–1.019 | 0.331 | - | - | - |
| Pathologic T stage (≥ pT3 vs. ≤ pT2) | 1.334 | 0.835–2.165 | 0.223 | - | - | - |
| Pathologic Gleason score (≥ 8 vs. < 7) | 1.497 | 0.136–16.51 | 0.742 | - | - | - |
| Pathologic Gleason score (7 [4 + 3] vs. 7 [3 + 4]) | 1.145 | 0.526–2.211 | 0.566 | - | - | - |
| Pathologic N stage (N1) | 6.581 | 0.596–72.61 | 0.124 | - | - | - |
| Tumor volume | 3.771 | 0.323–43.97 | 0.291 | - | - | - |
| Positive surgical margin | 2.129 | 0.341–13.26 | 0.419 | - | - | - |
| Seminal vesicle invasion | 2.776 | 0.288–26.73 | 0.377 | - | - | - |
| Lymphovascular invasion | 1.112 | 0.588–1.937 | 0.644 | - | - | - |
| No. of positive LNs | 2.175 | 0.562–8.415 | 0.261 | - | - | - |
| High grade PIN | 0.932 | 0.096–9.051 | 0.951 | - | - | - |
| PSA nadir period | 0.539 | 0.137–2.121 | 0.376 | - | - | - |
| Time to BCR | 0.956 | 0.925–0.989 | 0.009 | 0.948 | 0.892–1.007 | 0.083 |
| Salvage radiation therapy | 2.286 | 0.198–26.43 | 0.509 | - | - | - |
| Time to metastasis | 0.857 | 0.813–0.903 | < 0.001 | 0.885 | 0.816–0.959 | 0.003 |
CSM = cancer-specific mortality, PCa = prostate cancer, PSA = prostate-specific antigen, HR = hazard ratio, CI = confidence interval, BMI = body mass index, LN = lymph node, PIN = prostatic intraepithelial neoplasia, BCR = biochemical recurrence.