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The effect of HBK-17 (A), 8-OH-DPAT (C), and SB 269970 (D) on the behavior of mice in the four plate test and the influence of HBK-17 on the pain threshold (B). HBK-17 and SB 269970 were administered intraperitoneally 30 min before the experiment, whereas 8-OH-DPAT was injected 15 min before the four plate test. CONT – control group; Statistical analysis: one-way ANOVA (Newman-Keuls post hoc) ∗p < 0.05, ∗∗p < 0.01 vs. control group; n = 8–10 mice per group.
