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. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146

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Copyright © 2018 Pytka, Głuch-Lutwin, Żmudzka, Sałaciak, Siwek, Niemczyk, Walczak, Smolik, Olczyk, Gałuszka, Śmieja, Filipek, Sapa, Kołaczkowski, Pańczyk, Waszkielewicz and Marona.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of p-chlorophenylalanine [pCPA, (A)], WAY-100635 (B), or α-methylphenylalanine [AMPT, (C)] on anxiolytic-like activity of HBK-17 in the four plate test in mice. pCPA was injected intraperitoneally (i.p.) once daily for three consecutive days. Twenty-four hour after the last injection and 30 min before the test mice received (i.p.) either HBK-17 or 0.9% NaCl. WAY-100635 was administered subcutaneously 15 min before HBK-17. AMPT was injected (i.p.) 4 h before HBK-17. Vehicle-treated groups received 1% Tween (i.p.). Statistical analysis: two-way ANOVA (Bonferroni post hoc); ^∗p < 0.05, ^∗∗p < 0.01 vs. respective control group receiving vehicle or 1% Tween; ^#p < 0.05, ^##p < 0.01 vs. respective group receiving HBK-17 at the dose 5 mg/kg; n = 8 mice per group.