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The affinity of HBK-17 for adrenergic α2, dopaminergic D2, and GABAergic GABAA receptors.
| Compound | α2 receptors Ki ± SEM [nM] | D2 receptors Ki ± SEM [nM] | GABAA receptors Ki ± SEM [nM] |
|---|---|---|---|
| HBK-17 | 17800 ± 1.5 | 51.4 ± 0.7 | >10000 |
| Clonidine | 2.5 ± 0.1 | – | – |
| Haloperidol | – | 1.1 ± 0.1 | – |
| Diazepam | – | – | 5.6 ± 0.7 |
Inhibition constants (Ki) were calculated according to the equation of Cheng and Prusoff (1973).
