Table 5.
Pharmacokinetic parameters for HBK-17 after i.v. and i.p administration at a dose of 5 mg/kg to mice.
| Parameters |
|||
|---|---|---|---|
| i.v. | i.p. | ||
| C0 [ng/mL] | 1482 | – | |
| AUC0→∞ [ng . min/mL] | 55558 | 24877 | |
| MRT [min] | 107.9 | 101.4 | |
| t0.5 [min] | 105.4 | 149.9 | |
| Cmax [ng/mL] | – | 806.7 | |
| tmax [min] | – | 5 | |
| Vd [L/kg] | 13683.6 | – | |
| Cl [L/min/kg] | 90 | – | |
| F [%] | 44.8 | ||
C0, the initial concentration; Cmax, the maximum plasma concentration; tmax, time to reach the maximum plasma concentration; t1/2, terminal half-life; MRT, mean residence time; AUC0→∞, area under the concentration-time curve from zero up to infinitive time; Cl, systemic clearance; Vd, volume of distribution; F, bioavailability.