Table 2.
Toxicities and treatment compliance
| Factor | Grade | OPNI > 45 (n = 120) | OPNI 40–45 (n = 61) | OPNI < 40 (n = 39) | P |
|---|---|---|---|---|---|
| Any hematologic toxicity | G3/4 | 109 (90.8) | 57 (93.4) | 32 (82.1) | 0.230 |
| G4 | 81 (67.5) | 37 (60.7) | 23 (59.0) | 0.265 | |
| Anemia | G3 | 21 (17.5) | 12 (19.7) | 9 (23.1) | 0.439 |
| Thrombocytopenia | G3/4 | 23 (19.2) | 17 (27.9) | 14 (35.9) | 0.026 |
| G4 | 3 (2.5) | 7 (11.5) | 7 (18.0) | 0.001 | |
| Neutropenia | G3/4 | 108 (90.0) | 56 (91.8) | 31 (79.5) | 0.150 |
| G4 | 80 (66.7) | 37 (60.7) | 22 (56.4) | 0.214 | |
| Febrile neutropenia | G3/4/5 | 18 (15.0) | 15 (24.6) | 9 (23.1) | 0.149 |
| G4/5 | 7 (5.8) | 7 (11.5) | 3 (7.7) | 0.458 | |
| Any non‐hematologic toxicity | G3/4/5 | 38 (31.7) | 23 (37.7) | 17 (43.6) | 0.157 |
| G4/5 | 14 (11.7) | 10 (16.4) | 8 (20.5) | 0.150 | |
| Treatment‐related mortality | 6 (5.0) | 4 (6.6) | 3 (7.7) | 0.506 | |
| Early discontinuation of treatment | 7 (5.8) | 13 (21.3) | 10 (25.6) | < 0.001 | |
| Additional dose reduction | 41 (34.2) | 24 (39.3) | 9 (23.1) | 0.377 | |
Bold font indicates significant P values. Categorical variables are presented as number of patients (%).
OPNI, Onodera's Prognostic Nutritional Index.