Table 3.
Primary pharmacokinetic parameters after oral administration of AZD‐3759 in rats (n = 6, Mean ± SD)
| Pharmacokinetics parameters | Oral administration (n = 6) |
|---|---|
| AUC(0–t) (ng/mL·h) | 4301.756 ± 890.667 |
| AUC(0–∞) (ng/mL·h) | 4403.952 ± 904.901 |
| MRT(0–t) (h) | 9.178 ± 0.932 |
| MRT(0–∞) (h) | 9.649 ± 1.358 |
| t1/2 (h) | 3.481 ± 0.91 |
| Tmax (h) | 9 ± 1.897 |
| CL (L/h/kg) | 2.339 ± 0.403 |
| Vz (L/kg) | 11.781 ± 3.872 |
| Cmax (ng/mL) | 325.983 ± 63.936 |
AUC, area under the plasma concentration–time curve; CL, plasma clearance; Cmax, maximum plasma concentration; MRT, mean residence time; SD, standard deviation; t1/2, half‐life; Tmax, maximum plasma time.