Table 1.

Proteins with > 1.3‐fold differential expression between NCI‐H446 and 16‐HBE cells

No.	Protein ID	Description	Unique peptides	Protein Mass	Score	Coverage Rate	Fold change
1	P31327	Carbamoyl‐phosphate synthase (ammonia) (EC 6.3.4.16) precursor ‐ human	32	165 923.11	580.17	20.13%	2.55
2	P04181	ornithine aminotransferase precursor; Ornithine aminotransferase	2	48 846.33	52.31	6.15%	2.31
3	P49753	Mitochondrial Acyl‐CoA Thioesterase	4	46 723.68	119.87	12.81%	2.11
4	P07954	Fumarate hydratase, mitochondrial precursor (EC 4.2.1.2) (Fumarase)	3	54 773.23	110.42	26.27%	2.08
5	P55809	3‐oxoacid CoA transferase precursor; Succinyl CoA:3‐oxoacid CoA transferase; succinyl‐CoA:3‐ketoacid‐CoA transferase precursor; 3‐oxoacid CoA transferase 1	12	56 578.1	234.34	25.00%	1.99
6	P15531	Chain A, Nucleoside Triphosphate, Nucleoside Diphosphate Mol_id: 1; Molecule: Nucleoside Diphosphate Kinase; Chain: A, B, C, D, E, F; Ec: 2.7.4.6	2	17 269.94	76.54	23.84%	1.93
7	P50395	GDP dissociation inhibitor 2; rab GDP‐dissociation inhibitor, beta	3	51 087.05	106.85	18.65%	1.84
8	P50750	tat‐associated protein	13	31 364.49	276.95	33.33%	1.83
9	P08670	(XM_042950) vimentin	76	53 676.1	815.46	43.99%	1.78
10	Q13423	NAD(P) transhydrogenase (B‐specific) (EC 1.6.1.1) precursor, mitochondrial	8	114 591.75	210.75	6.91%	1.67
11	P60174	triosephosphate isomerase 1	4	26 937.85	117.68	39.76%	1.58
12	P08133	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin 20) (67 kDa calelectrin) (Calphobindin‐II) (CPB‐II)	2	76 167.7	110.25	10.70%	1.52
13	Q02218	OGDH protein	4	117 058.85	160.97	9.97%	1.51
14	P51149	small GTP binding protein Rab7	12	23 731.92	214.15	30.92%	1.51
15	O75431	metaxin 2	3	30 086.2	77.78	17.49%	1.48
16	Q99714	3‐hydroxyacyl‐CoA dehydrogenase, isoform 2	5	42 438.94	108.26	13.59%	1.47
17	Q969X5	transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment; type‐II transmembrane protein p63	23	66 096.77	472.48	29.90%	1.46
18	Q9H9B4	Sideroflexin 1	7	35 881.45	88.55	10.87%	1.45
19	O75390	citrate synthase precursor isoform a; citrate synthase, mitochondrial	4	51 907.6	76.40	5.58%	1.42
20	Q96TA2	YME1‐like 1 isoform 3; ATP‐dependent metalloprotease FtsH1 homolog	2	80 010.64	72.02	5.31%	1.42
21	P35613	basigin isoform 1; OK blood group; emmprin; collagenase stimulatory factor; M6 antigen; extracellular matrix metalloproteinase inducer	8	42 573.21	136.57	21.82%	1.39
22	Q9NS69	mitochondrial import receptor Tom22	8	15 511.78	163.04	61.97%	1.39
23	P00558	Phosphoglycerate kinase 1 (Primer recognition protein 2) (PRP 2)	6	45 098.36	176.42	26.08%	1.37
24	P31937	3‐hydroxyisobutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.31) (HIBADH)	3	35 704.91	130.92	11.01%	1.37
25	P62937	peptidylprolyl isomerase A isoform 1; cyclophilin A; peptidyl‐prolyl cis‐trans isomerase A; T cell cyclophilin; rotamase; cyclosporin A‐binding protein	29	18 228.97	304.08	51.52%	1.36
26	P04843	Similar to ribophorin I	9	64 655.75	187.58	22.54%	1.35
27	Q9HAV0	guanine nucleotide‐binding protein, beta‐4 subunit; guanine nucleotide binding protein subunit beta 4; G protein beta‐4 subunit	9	38 284.3	193.47	17.65%	1.33
28	O60313	Dynamin‐like 120 kDa protein, mitochondrial, EC 3.6.5.5	3	114 017.03	128.97	11.25%	1.32
29	P22570	ferredoxin reductase isoform 2 precursor; adrenodoxin reductase	2	54 929.52	78.16	9.05%	1.30
30	P13995	methylene tetrahydrofolate dehydrogenase 2 precursor; NAD‐dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase	3	37 467.98	80.97	11.92%	1.30