TABLE 3.
Serum cytokine and chemokine concentrations in 33 participants classified by adiposity and BMI1
Adiposity | BMI | ||||
---|---|---|---|---|---|
Normal adiposity, n = 12 | High adiposity, n = 21 | Normal weight, n = 8 | Overweight, n = 14 | Obese, n = 11 | |
Cytokines | |||||
Proinflammatory | |||||
IL-1β, pg/mL | 3.14 ± 2.31 | 2.78 ± 2.85 | 2.78 ± 2.27 | 3.73 ± 3.09 | 1.98 ± 2.09 |
IL-6, pg/mL | 2.53 ± 1.51 | 16.6 ± 57.9 | 2.33 ± 1.12 | 23.9 ± 70.6 | 2.28 ± 1.48 |
TNF-α, pg/mL | 10.2 ± 10.6 | 11.5 ± 15.2 | 6.31 ± 5.98 | 15.9 ± 17.5 | 8.32 ± 10.1 |
G-CSF, pg/mL | 94 ± 143 | 102 ± 168 | 59 ± 153 | 150 ± 181 | 62 ± 116 |
IFN-γ, pg/mL | 2.8 ± 3.7 | 54 ± 145 | 1.3 ± 1.5 | 81 ± 173 | 1.72 ± 2.67 |
Anti-inflammatory | |||||
IL-10, pg/mL | 6.5 ± 3.4 | 25.2 ± 67.2 | 7.7 ± 4.7 | 32.5 ± 81.9 | 8.3 ± 9.2 |
TGF-β1, ng/mL | 39.3 ± 47.6 | 27.0 ± 31.4 | 31.7 ± 32.6 | 43.6 ± 50.6 | 15.8 ± 14.8 |
TGF-β2, pg/mL | 276 ± 176 | 311 ± 253 | 316 ± 680 | 334 ± 205 | 221 ± 184 |
TGF-β3, pg/mL | 140 ± 125 | 282 ± 354 | 92 ± 55 | 252 ± 301 | 305 ± 372 |
Chemokines | |||||
IL-8, pg/mL | 42.0 ± 31.8 | 41.0 ± 17.4 | 36.7 ± 12.8 | 50.1 ± 31.0 | 33.59 ± 12.7 |
MCP-1, pg/mL | 89.8 ± 127 | 69.2 ± 81 | 59 ± 57 | 102 ± 135 | 56 ± 64 |
MIP-1α, pg/mL | 13.1 ± 6.9 | 6.9 ± 5.1 | 8.55 ± 9.82 | 8.86 ± 6.43 | 9.99 ± 8.03 |
MIP-1β, pg/mL | 712 ± 1010 | 400 ± 278 | 348 ± 181 | 613 ± 930 | 507 ± 410 |
RANTES, ng/mL | 78.3 ± 53.6 | 91.8 ± 44.9 | 83.9 ± 52.2 | 95.3 ± 42.6 | 78.3 ± 53.7 |
1Values are means ± SDs. No differences were reported between adiposity or BMI classifications. G-CSF, granulocyte-colony–stimulating factor; MCP-1, monocyte chemoattractant protein 1; MIP, macrophage inflammatory protein; RANTES, regulated on activation, normal T-cell expressed and secreted.