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. 2018 Oct 25;9:1138. doi: 10.3389/fphar.2018.01138

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Copyright © 2018 Ma, Yu, Chen, Li, Ihsan, Tong, Huang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of sweroside pretreatment on calcium-related gene mRNA expression in H9c2 cells. (A) SCN5A mRNA expression level was measured; the data showed that aconitine markedly increased SCN5A mRNA expression, however, sweroside effectively reversed this increase. (B–D) Sweroside reduced aconitine-induced enhancement of RyR2, DHPR, SERCA2a mRNA expression, respectively. n = 3 (n, the number of experiments), ^#P < 0.05 and ^##P < 0.01 vs. control, ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 vs. aconitine group.