Table 2.
Comparative differencesa in calcified plaque measurements among 35 146 asymptomatic women and men with detectable coronary artery calcium (score >0) enrolled in the CAC Consortium
| CAC measures | CAC 1–100 (n = 19 684) |
CAC 101–399 (n = 8612) |
CAC ≥400 (n = 6850) |
||||
|---|---|---|---|---|---|---|---|
| Women (n = 5236) | Men (n = 14448) | Women (n = 1840) | Men (n = 6772) | Women (n = 1039) | Men (n = 5811) | Sex interaction P value | |
| CAC Score | 28 ± 28 | 28 ± 37 | 204 ± 81 | 213 ± 85 | 1025 ± 826 | 1161 ± 964 | <0.0001 |
| Number of calcified vessels | 1.5 ± 0.7 | 1.6 ± 0.8 | 2.4 ± 0.9 | 2.6 ± 0.9 | 3.2 ± 0.7 | 3.3 ± 0.6 | 0.008 |
| Number of calcified lesions | 2.6 ± 2.4 | 3.5 ± 3.3 | 6.9 ± 4.2 | 9.5 ± 5.9 | 15.9 ± 9.2 | 20.2 ± 11.1 | <0.0001 |
| CAC volume (mm3) | 24 ± 22 | 25 ± 23 | 161 ± 66 | 172 ± 69 | 790 ± 578 | 932 ± 772 | <0.0001 |
| CAC density (HU) | 192 ± 43 | 184 ± 37 | 248 ± 43 | 234 ± 37 | 268 ± 39 | 258 ± 36 | 0.013 |
| Mean lesion size (mm3) | 12 ± 11 | 10 ± 10 | 36 ± 30 | 28 ± 20 | 65 ± 48 | 57 ± 43 | <0.0001 |
The mean and standard deviation (±) values are reported in each of the cell subgroups. The sex interaction P value is for each of the CAC measures listed in each row of this table.
a
Comparative analysis using general linear model with subsets by sex and Agatston score subgroups. P value is a test for interaction of the Agatston score subgroups by sex. Explanatory variance (or r2) was moderate and ranged from 0.38 to 0.53 for all measures. Non-parametric analysis comparing independent samples provided similar results.