Table 3.

Relative hazard (and 95% confidence intervals)^a for estimating cardiovascular disease mortality by coronary artery calcium score measurements among asymptomatic women and men enrolled in the CAC Consortium

	N	Women	P value	n	Men	P value	Interaction P value
CAC score subgroups		(n = 20 508)			(n = 42 707)
1–100	5236	2.93 (2.00–4.29)	<0.0001	14 448	2.13 (1.59–2.85)	<0.0001	0.887
101–399	1840	9.72 (6.70–14.09)	<0.0001	6772	4.98 (3.73–6.65)	<0.0001	<0.0001
≥400	1039	26.65 (18.07–36.41)	<0.0001	5822	13.32 (10.25–17.32)	<0.0001	<0.0001
Number of calcified vessels		(n = 20 508)			(n = 42 707)
1 vessel	2840	2.40 (1.49–3.87)	<0.0001	6203	1.91 (1.32–2.78)	0.001	0.589
2 vessels	1801	6.57 (4.89–10.66)	<0.0001	5413	3.29 (2.35–4.61)	<0.0001	<0.0001
3 vessels	1286	11.41 (7.69–16.94)	<0.0001	5667	7.88 (5.91–10.52)	<0.0001	<0.0001
4 vessels	457	28.22 (18.61–42.80)	<0.0001	2747	10.85 (7.96–14.78)	<0.0001	<0.0001
CAC volume (mm3)		(n = 10 394)			(n = 20 209)
0.2–15.0	1111	3.09 (1.54–6.22)	0.002	2876	1.83 (1.11–3.00)	0.025	0.750
15.1–61.5	1159	4.02 (2.13–7.62)	<0.0001	2872	2.06 (1.28–3.33)	0.004	0.792
61.6–230.3	931	8.40 (4.79–14.72)	<0.0001	3081	3.77 (2.51–5.68)	<0.0001	<0.0001
≥230.4	657	28.81 (17.73–46.82)	<0.0001	3353	9.90 (6.96–14.08)	<0.0001	<0.0001

For this analysis, separate Cox models were calculated for women and men; with the right column including the interaction P value of women vs. men in a combined predictive model.

^aAdjusted by the PCE risk score. No CAC was scored as 0 and is the comparator for this analysis. Coronary artery calcium volume was categorized into quartiles.