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Drugs/inhibitors used in this study and their molecular targets.
| Drug/Inhibitor | Molecular Target |
|---|---|
| Temsirolimus | mTOR, FKBP12 |
| Everolimus | mTOR, FKBP12 |
| Sunitinib | VEGFR2 (Flk-1) and PDGFRβ |
| Sorafenib | Raf-1, B-Raf and VEGFR-2 |
| Pazopanib | VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms |
| Afuresertib (GSK2110183) | Akt |
| Sapitinib (AZD8931) | EGFR, ErbB2 and ErbB3 |
| FLI-06 | Notch |
| U73122 | Phospholipase C (PLC) |
