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. 2018 Oct 16;10(10):385. doi: 10.3390/cancers10100385

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of phenformin on syngeneic ID8 tumors in SP^−/− and SP^+/+ mice. (A) Schema of the mouse therapeutic trial with phenformin. (B) Scatter plots showing the effect of phenformin on syngeneic tumor burden in SP^−/− and SP^+/+ mice. p < 0.05. (C) Bars depict mean ± SEM of the levels of H₂O₂ in syngeneic tumors determined by DCF fluorescence. p < 0.05, Student’s t-test. (D) Immunostaining of syngeneic tumors with the indicated antibodies (200×).