Table 2.
List of CRFs/CDEs discussed in this companion manuscript. Files can be located online as Supplemental Material
| CRF/CDE module name | Primary study objective | Route of seizure induction | Outcome measures |
|---|---|---|---|
| 1 General core pharmacology | Pharmacologic testing information | N/A | Drug information (route of administration, frequency, vehicle, solubility, etc.) |
| 2 MES and MEST | Antiseizure test | Electroconvulsant | Maximal electroshock seizure and maximal electroshock seizure threshold ‐ individual seizure response; population seizure threshold |
| 3 Acute 6 Hz | Antiseizure test | Electroconvulsant | 6 Hz seizure and 6 Hz seizure threshold – individual seizure response; population seizure threshold |
| 4 Subcutaneous chemoconvulsant | Antiseizure test | Chemoconvulsant | Chemonconvulsant seizure and chemoconvulsant seizure threshold – individual seizure response; population seizure threshold |
| 5 Timed intravenous chemoconvulsant infusion test | Antiseizure test | Chemoconvulsant | Chemoconvulsant seizure threshold – individual seizure threshold response |
| 6 Intracerebral electrical kindling | Antiseizure test; antiepileptogenesis test | Electroconvulsant | Antiseizure testing: acute protection from seizures; antiepileptogenesis testing: modification of kindling acquisition or behavioral comorbidities |
| 7 Corneal kindling | Antiseizure test; antiepileptogenesis test | Electroconvulsant | Antiseizure testing: acute protection from seizures; antiepileptogenesis testing: modification of kindling acquisition or behavioral comorbidities |
| 8 Chemoconvulsant kindling | Antiseizure test; antiepileptogenesis test | Chemoconvulsant | Antiseizure testing: acute protection from seizures; antiepileptogenesis testing: modification of kindling acquisition or behavioral comorbidities |
| 9 CS_SE | Antiseizure test; antiepileptogenesis test | Chemoconvulsant | Antiseizure testing: modification of SE, or protection from acute symptomatic seizures; antiepileptogenesis testing: modification of SRS frequency, or behavioral comorbidities, or neuropathology |
| 10 CS_ESE | Antiseizure test; antiepileptogenesis test | Electroconvulsant (self‐sustained) | Antiseizure testing: modification of SE, or protection acute symptomatic seizures; antiepileptogenesis testing: modification of SRS frequency, or behavioral comorbidities, or neuropathology |
| 11 CS_fKASE | Antiseizure test; antiepileptogenesis test | Chemoconvulsant | Antiseizure testing: modification of SE, or protection from acute symptomatic seizures; antiepileptogenesis testing: modification of SRS frequency, or behavioral comorbidities, or neuropathology |