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. 2018 Oct 4;3(10):12658–12678. doi: 10.1021/acsomega.8b01237

Figure 8.

Figure 8

Pharmacokinetics of 28 in male SD rats. Rats were fasted overnight for three oral doses, but fed for the i.v. dose. The in vivo half-life (t1/2, h, p.o.) of 28 was 1 mg/kg, 2.16 ± 0.45; 3 mg/kg, 1.55 ± 0.42; 10 mg/kg, 1.91 ± 0.28. The t1/2 for the i.v. dose was 1.31 ± 0.06 h. Oral bioavailability (% F) and other pharmacokinetic parameters (units) are indicated: MRT (mean residence time, h); AUC (area under the curve, time 0 to ∞, ng·h/mL); Cl (clearance, mL/min/kg); Vd (volume of distribution, L/kg); Cmax = 10.0 ± 8.3 (max. concentration, ng/mL); Tmax (time at max. concentration, h).