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Quantitative fitness measurements identify redundant catabolic pathways for PCA. Strain DSM12444 has two redundant pathways for catabolism of PCA: a 4,5-cleavage pathway and a 2,3-cleavage pathway. Disruption of the canonical 4,5-cleavage pathway produces an average 76% decrease in fitness, while disruption of the 2,3-cleavage pathway decreases fitness by an average of 39%. Error bars show one standard deviation, calculated from three biological replicates.
