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Risk of grade ≥3 diarrhea with afatinib treatment (40 mg or 50 mg starting dose) by count of risk factors 1.
| Risk Factors 1 | Events/Patients (%) | |
|---|---|---|
| 40 mg Afatinib | 50 mg Afatinib | |
| 0 | 5/90 (6%) | 9/119 (8%) |
| 1 | 17/238 (7%) | 51/312 (16%) |
| 2 | 23/152 (15%) | 64/198 (32%) |
| 3 | 6/18 (33%) | 9/21 (43%) |
1 Female sex, age ≥60 years, and body weight <45 kg.
