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. 2018 Oct 22;10(10):390. doi: 10.3390/cancers10100390

Figure 2.

Figure 2

Association of NCL expression levels with poor prognosis in breast cancer subtypes using Dundee series. Overall (A,C,E) and disease-free survivals (B,D,F) in relation to NCL expression levels were analysed in tumours exhibiting different hormonal status: ER+ PR+/− HER2− (equivalent to the luminal subtype, A,B); ER+/− PR+/− HER2+ (equivalent to the HER2 subtype, C,D); and ER− PR− HER2− (equivalent to the triple-negative subtype, E,F). While NCL expression levels were not associated with survivals in patients carrying ER+ PR+/− HER2− and ER+/− PR+/− HER2+ tumours, associations were observed between NCL expression levels and both overall and disease-free survivals in patients bearing ER− PR− HER2− tumours. The association between NCL expression levels and survival was analysed using Kaplan–Meier representation. Number of subjects at risk is indicated on the graph for the three NCL groups (low; intermediate; high). Log-rank p-value ≤ 0.05 was used to determine significant association.