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. 2018 Oct 15;7(10):171. doi: 10.3390/cells7100171

Figure 8.

Figure 8

Gene expressions of UPR genes, Survivin, and measurement of inflammatory cytokines of cells treated with YM155.mRNA expression of UPR genes: (A) IAP gene Survivin, (B) Grp78, (C) XBP1, (D) PERK, and (E) ATF6 in LS174T cells treated with TUN 10 µg/mL and 100 nM of YM155 for 6hours normalized to GAPDH (n = 3).The data are shown as the mean fold change ± SEM (significance testing vs. TUN: *, **, ***, ****; p < 0.05, p < 0.01, p < 0.001 and p < 0.0001, respectively). (F) Representative Western blot for Survivin and Grp78. The bands were normalized with β-Actin and quantified. (G,H) represents Western blot quantification. Cytokine expression of (I) IL8, (J) IL10, (K) IL4, and (L) IL6 in LS174T cells treated with TUN 10 µg/mL and 100 nM of YM155.