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Time-line of HACA development during treatment with ch14.18/CHO. Serum samples collected from 122 pts treated with up to five cycles of ch14.18/CHO immunotherapy were analyzed in every cycle with a validated ELISA allowing for the detection of anti-ch14.18/CHO Abs (HACA). The cumulative incidence of HACA in treated pts during the treatment period is shown over time (black solid line). For a better overview, the end of the respective cycle is indicated by dashed vertical lines.
