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. 2018 Oct 17;10(10):387. doi: 10.3390/cancers10100387

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ch14.18/CHO-mediated CDC and impact of HACA response. Induction of GD₂-specific ch14.18/CHO-mediated CDC in HACA-negative (A) and HACA-positive pts who developed non-neutralizing (B) and neutralizing anti-ch14.18/CHO Ab (C) was analyzed. CDC was tested in cycles 1, 3 and 5 on d8 after the start of Ab infusion (i.e., d15; closed circles) and compared to the baseline CDC of the respective cycle (d1; open circles) using the cytotoxicity assay as described in “Materials and Methods”. The circles represent pts evaluable for the analysis. Experiments were performed in six replicates. White (non-neutralizing) and black solid horizontal bars (neutralizing) indicate mean values of the respective group. t-test or Mann-Whitney Rank Sum test. *** p < 0.001 vs. d1 of the respective cycle; ^§§§ p < 0.001 vs. d1, cycle 1; ^## p < 0.001 vs. d1, cycle 3.