Table 3.
The clinical trials of oncolytic viruses in patients with glioma.
| Oncolytic Virus | Phase | Administration Route | Combination | Status | Trial No. | Reference |
|---|---|---|---|---|---|---|
|
HSV1716
Seprehvir® |
I | IT | ---- | Completed | PMID10845724 | [60] |
| Ib | IT | ---- | Completed | PMID11960316, PMID15334111 |
[61,62] | |
| II | IT | ---- | Completed Not reported |
NCT02031965 | ||
| G207 | I | IT | ---- | Completed | NCT00028158 | [64] |
| Ib | IT | ---- | Completed | NCT00157703 | [65,66] | |
| I | IT | 5Gy radiation dose | Completed | NCT00157703. | [67] | |
| G47∆ | I | IT | ---- | Completed Not reported |
[69] | |
| II | IT | ---- | Ongoing | UMIN000011636 | [69] | |
| MO32 | I | IT | Ongoing | NCT02062827 | [58] | |
| rQNestin | I | IT | Recruiting | NCT03152318 | ||
| ONYX-015 | I | IT | ---- | Completed | PMID15509513 | [70] |
|
Adeno-Delta-24-RGD
(DNX-2401) |
I | IT | ---- | Completed | [71,72] | |
| I | temozolomide | Ongoing | NCT01956734 | |||
| I | interferon-γ | Ongoing | NCT02197169 | |||
|
Pelareorep (Reolysin®) |
I | IV | ---- | Completed | NCT00528684 | [73] |
| I | IV | ---- | Completed | PMID: 24553100 | [74] | |
| Newcastle Disease Virus (NDV) | I/II | IT | ---- | Completed | NCT01174537 | [75] |
| Parvovirus H-1 (ParvOryx) | I | IT and IV | ---- | Completed | NCT01301430 | [76] |
| Measles virus CEA | I | IT | ---- | Ongoing | (NCT00390299) | |
| Poliovirus PVSRIPO | I | IT | ---- | Completed | (NCT01491893) | [77] |
| Toca 511 | I | IT | ---- | Ongoing | (NCT02576665) | |
| Vaccinia virus TG6002 | I | IT | ---- | Ongoing | (NCT03294486) |