Table 3.
Characteristics of head and neck squamous cell carcinoma (HNSCC) patients with curative-intent treatment.
| Number of Patients | |||
|---|---|---|---|
| MDSC (Low) | MDSC (High) | p-Value | |
| Patients | 59 | 59 | |
| Age | |||
| <55 (median) | 28 | 26 | 0.72 |
| ≥55 | 31 | 33 | |
| Differentiation | 0.15 | ||
| Well differentiated | 12 | 9 | |
| Moderately differentiated | 24 | 18 | |
| Poorly differentiated | 17 | 23 | |
| Unknown | 6 | 9 | |
| Tumor stage | 0.005 * | ||
| ≤T2 | 35 | 20 | |
| T3–T4 | 24 | 39 | |
| Clinical LN involvement | 0.018 * | ||
| Negative | 25 | 13 | |
| Positive | 34 | 46 | |
| Tx policy | 0.016* | ||
| Definite CCRT | 26 | 39 | |
| Surgery +/− neoadjuvant/adjuvant Tx | 33 | 20 | |
| Location | 0.19 | ||
| Oral cavity | 29 | 22 | |
| Pharynx (Oro-Hypo) | 30 | 37 | |
| NLR | <0.001 * | ||
| <3 | 51 | 13 | |
| ≥3 | 8 | 46 | |
| ALDH1 staining | <0.001 * | ||
| Negative | 55 | 9 | |
| Positive | 4 | 50 | |
| Disease failure | <0.001 * | ||
| Negative | 52 | 26 | |
| Positive | 7 | 33 | |
| Status | <0.001 * | ||
| Alive | 54 | 34 | |
| Dead | 5 | 25 | |
MDSC: myeloid-derived suppressor cell; *: Statistically significant covariate.