Table 7.
Adjusted hazard ratio (HR) of determining factors associated with disease failure of patients with head and neck squamous cell carcinoma (HNSCC).
| Variable | HR | 95% CI | p-Value |
|---|---|---|---|
| Age | |||
| <50 | Ref | ||
| ≥50 | 1.12 | 0.71–1.77 | 0.62 |
| Differentiation | |||
| Well–Moderately differentiated | Ref | ||
| Poorly differentiated | 0.88 | 0.53–1.47 | 0.63 |
| Clinical T stage | |||
| ≤T2 | Ref | ||
| T3–T4 | 1.1 | 0.70–1.71 | 0.68 |
| Clinical N stage | |||
| N 0 | Ref | ||
| N (+) | 1.26 | 0.78–2.03 | 0.35 |
| ALDH1 | |||
| Negative | Ref | ||
| Positive | 5.92 | 3.46–10.11 | <0.001 * |
| Treatment | |||
| Definite CCRT | Ref | ||
| Surgery +/− neoadjuvant/adjuvant Tx | 0.42 | 0.25–0.71 | 0.001 * |
*: Statistically significant covariate.