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Schematic representation of human Duox1 and C. elegans BLI-3/Duox. (A) Human Duox1. (B) C. elegans BLI-3/Duox. Arrowheads and arrows indicate mutation; in italics are the allele names; and below, the amino acid substitution. (C) Proposed topology model of C. elegans BLI-3/Duox. For (A–C), TM = transmembrane region, EF = EF-hand, NoD = NADPH oxidase domain.
