Table 3.
Sensitivity analysis.
| New-Onset DM | Non-DM Death | |||||||
|---|---|---|---|---|---|---|---|---|
| aHR a (95% CI) | p Value | aHR b (95% CI) | p Value | aHR a (95% CI) | p Value | aHR b (95% CI) | p Value | |
| Adjusted for the propensity score | ||||||||
| Comparison cohort | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ESRD dialysis cohort | 0.53 (0.43–0.65) | <0.0001 | 0.57 (0.46–0.7) | <0.0001 | 1.85 (1.66–2.06) | <0.0001 | 1.78 (1.6–1.98) | <0.0001 |
| PD | 0.98 (0.55–1.74) | 0.94 | 0.99 (0.56–1.75) | 0.96 | 1.89 (1.7–2.11) | <0.0001 | 1.81 (1.63–2.01) | <0.0001 |
| HD | 0.50 (0.40–0.63) | <0.0001 | 0.54 (0.43–0.67) | <0.0001 | 1.24 (0.85–1.81) | 0.27 | 1.29 (0.89–1.86) | 0.18 |
| Kidney transplant as a censored covariate | ||||||||
| Comparison cohort | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ESRD dialysis cohort | 0.50 (0.40–0.63) | <0.0001 | 0.53 (0.43–0.65) | <0.0001 | 2.32 (2.07–2.59) | <0.0001 | 2.24 (2.02–2.49) | <0.0001 |
| PD | 0.87 (0.46–1.64) | 0.66 | 0.89 (0.47–1.65) | 0.7 | 2.30 (1.54–3.44) | <0.0001 | 2.46 (1.67–3.61) | <0.0001 |
| HD | 0.47 (0.37–0.60) | <0.0001 | 0.50 (0.40–0.63) | <0.0001 | 2.31 (2.06–2.58) | <0.0001 | 2.22 (1.99–2.47) | <0.0001 |
| Change of renal replacement therapy as time-dependent covariates | ||||||||
| Comparison cohort | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ESRD dialysis cohort | 0.54 (0.43–0.67) | <0.0001 | 0.53 (0.43–0.66) | <0.0001 | 2.31 (2.06–2.58) | <0.0001 | 2.23 (2–2.47) | <0.0001 |
| PD | 0.96 (0.54–1.71) | 0.88 | 0.93 (0.51–1.69) | 0.81 | 2.49 (1.65–3.77) | <0.0001 | 2.47 (1.63–3.75) | <0.0001 |
| HD | 0.51 (0.40–0.64) | <0.0001 | 0.50 (0.40–0.62) | <0.0001 | 2.30 (2.06–2.57) | <0.0001 | 2.22 (1.99–2.47) | <0.0001 |
| Change of dialysis mode or kidney transplant as censored covariates | ||||||||
| Comparison cohort | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ESRD dialysis cohort | 0.57 (0.45–0.71) | <0.0001 | 0.61 (0.5–0.75) | <0.0001 | 2.43 (2.18–2.72) | <0.0001 | 2.36 (2.13–2.62) | <0.0001 |
| PD | 1.13 (0.6–2.14) | 0.7 | 1.37 (0.73–2.56) | 0.33 | 3.8 (2.5–5.79) | <0.0001 | 4.39 (3.02–6.38) | <0.0001 |
| HD | 0.54 (0.43–0.68) | <0.0001 | 0.59 (0.47–0.73) | <0.0001 | 2.4 (2.14–2.68) | <0.0001 | 2.32 (2.08–2.57) | <0.0001 |
Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval; HD, hemodialysis; PD, peritoneal dialysis. a Adjusted for all variables in Table 1 by Cox proportional hazard model with Fine and Grey’s method to consider death as a competing risk. b Adjusted for all variables in Table 1 by stepwise Cox proportional hazard model (SLENTRY = 0.15 and SLSTAY = 0.15) with cause-specified method to consider death as a competing risk.