Figure 2.

Strategies for targeting TAMs in ovarian cancer. (A) Block monocyte recruitment to the tumor niche. (B) Chemical intervention to increase M1/M2 ratio by inhibiting M2 polarization, increasing M1 polarization by using Interferon gamma (IFN-ƴ, Lipopolysaccharide (LPS)) or by repolarizing M2 to M1 by adding IFN-ƴ or regulating the Notch, NF-κB. (C) Inhibit immune signaling pathways on macrophages, for e.g., CSF-1, VEGFR, which promotes angiogenesis, and PD-L1, which inhibits T cell activity.