Table 1.

Summary of studies included

Study	Type of study	Outcome	Inclusion criteria	Exposure	Pregnancies
Barad et al., 2007	Case control	Mean number of oocytes recovery Implantation rate Clinical Pregnancy rate Abortion rate	FSH >12mIU/ml E2≥75pg/ml	25mg tid for 4 months	DHEA group: 13/64 pregnancies Control group: 11/101 pregnancies
Wiser et al., 2010	Randomized controlled trial	Mean number of oocytes recovery Clinical Pregnancy rate Abortion rate	Previous IVF cycle with more than 300IU rFSH/day Less than 5 embryos	25mg tid for 6 weeks	DHEA group: 04/16 pregnancies Control group: 2/16 pregnancies
Xu et al., E22014	Retrospective	Implantation rate Clinical Pregnancy rate	Two or more of following: ≥40years <4 oocytes recovered in previous cycle <5AFC	25mg tid for 90 days	DHEA group: 57/189 pregnancies Control group :37/197 pregnancies
Vlahos et al., 2015	Prospective	Clinical Pregnancy rate Delivery of a live born	Two of following: ≥40years <3 oocytes recovered in previous cycle E2 peak <500pg/ml	25mg tid for 12 weeks	DHEA group: 1/48 pregnancies in Control group 8/113 pregnancies
Kotb et al., 2016	Randomized controlled trial	Clinical Pregnancy rate	Bologna criteria	25mg tid for 3 months	DHEA group 20/70 pregnancies Control group: 9/70 pregnancies