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. 2018 Oct 11;10(10):379. doi: 10.3390/cancers10100379

Figure 1.

Figure 1

The hierarchical clustering and principal component analysis (PCA) of 190 significantly differentially expressed genes in 20 matched Pre-ADT biopsies and Post-ADT radical prostatectomies (RPs). (A) Clustering reveals two groups of Post-ADT RPs displaying segregated based on the expression of upregulated and downregulated genes (high- or low-impact groups, respectively); (B) Volcano plot highlighting 190 significantly differentially expressed genes; (C) PCA reveals 4 post-ADT RP samples as not clustering with either the high or low impact groups; (D) Boxplot depicting KLK3 expression in counts per million mapped reads demonstrates that the decrease in the KLK3 expression is significantly more pronounced in the high impact group than in the low impact group.