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(A) Diagram to skull base structure. (B) Differential Cre-dependent recombination in the skull bases of P0 and Wnt1 Cre lines. Indicated Cre mice were crossed with Rosa26-LacZ Cre reporter mice, followed by beta-galactosidase activity staining to visualize the Cre recombinant cells in the skull base. PS, presphenoid bone; ISS, intersphenoidal synchondrosis; BS, basisphenoid bone; SOS, spheno-occipital synchondrosis. Scale bar = 100 μm.
