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. 2018 Sep 20;10(10):342. doi: 10.3390/cancers10100342

Figure 1.

Figure 1

The activation of HER receptors and the downstream signaling cascades. Four members of HER receptors interact with 11 ligands, which results in the formation and the activation of 10 different homo- and heterodimers. Activated HER receptors promote many signaling cascades affecting many key biological outcomes.