Figure 2.

Multiple effects of SFN/CUR: SFN/CUR shows its anti-cancer effect in PCa by activation of Nrf-2 signaling and inhibition of NF-κB as well as AR signaling. As these three pathways are interlinked with each other, it leads to the upregulation of antioxidant proteins and downregulation of inflammatory proteins eventually resulting in the overall suppression of AR signaling and PCa growth.