Figure 3.

Cold physical plasma-derived generation and delivery of ROS/RNS triggers redox modifications and accelerates physiological responses in wound healing. Redox sensitive signaling pathways (e.g., Nrf2, p53) provide protection from excess ROS/RNS to eventually re-establish redox homeostasis. Cold physical plasma-derived ROS/RNS are efficient triggers of such signaling events in skin cells in vitro and in vivo. Accordingly, plasma treatment promotes several cellular and tissue responses linked to molecular signatures accompanying enhanced wound healing.