Fig. 2.

Effect of acyl-PAF on PAF-R dampening in alkyl-PAF-mediated lethality in Swiss albino mice. Mice (20–25 g) were divided into 9 groups containing 6 mice each. In this experiment each group of mice was injected with the indicated amount of acyl-PAF (2.5–50 mg/kg) in a total volume of 0.5 ml PBS containing 0.1% HSA. After 3 h, the same mice were injected with a lethal dose of alkyl-PAF (250 µg/kg), and survival time was monitored. The control group received only alkyl-PAF at a dose of 250 µg/kg, and all of the mice died between 15 and 20 min. The survival of mice was monitored for up to 6 days. The open bar represents the time of death in minutes, and the solid line represents the percentage survival of individual groups of mice. The best representative results of three individual experiments are shown.