Fig. 3.

Reactivation of PAF-R in Swiss albino mice pretreated with acyl-PAF or WEB-2086. Swiss albino mice (20–25 g) were assigned into 13 groups containing 6 mice each. Each group of mice was pretreated with acyl-PAF (12.5 mg/kg) or WEB-2086 (30 mg/kg) for various time intervals (0–45 h), followed by a lethal dose of alkyl-PAF (250 μg/kg) in a final volume of 0.5 ml PBS containing 0.1% HSA. Control mice received the vehicle used in the preparation of acyl-PAF or alkyl-PAF (PBS containing 0.1% albumin) or WEB-2086 (DMSO + PBS). The survival of mice was monitored for up to 6 days. The best representative results of three individual experiments are shown.